chapter 13, Nanomechanical Cantilever Biosensors: Conceptual Design, Recent Developments, and Practical Implementation

In Part 3: Modeling, Section 2: Medical Devices from: Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling

Editor(s): Ahmed Al-Jumaily, Azra Alizad

Published: 2008

Author(s)/Editor(s): Mana Afshari, Nader Jalili

Chapter DOI: http://dx.doi.org/10.1115/1.802755.ch13

Chapter Page Count: 22 pages

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Front Matter

Part 1: Therapy, Section 1: Respiratory System
1. Oscillation of Airway Smooth Muscle as a Potential Non-Medicinal Treatment for Asthma

2. Oscillatory Ventilation in the Treatment of Neonatal Respiratory Diseases

Part 1: Therapy, Section 2: Nervous System
3. Ultrasound-Induced Treatment of Neurodegenerative Diseases across the Blood-Brain Barrier

Part 1: Therapy, Section 3: Cell Culture
4. Effects of Mechanical Vibration on Cultured Osteoblasts in Relation to Fracture Healing

5. Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture in Relation to the Production of Regenerative Cartilage Tissue

Part 2: Bioeffects
6. Risk Factors and Interventions Associated with Hand-Arm Vibration Syndrome

7. Vibration and the Sensory System

Part 3: Modeling, Section 1: Biological Systems
8. Occlusion Identification and Relief within Branched Structures

9. Advances in Computational Modeling of Sound Propagation in the Lungs and Torso with Diagnostic Applications

10. An Investigation into the Dynamic Response of Vocal Folds

Part 3: Modeling, Section 2: Medical Devices
11. Acoustic Noise in MRI Scanners

12. Vibration in MRI Scanners

13. Nanomechanical Cantilever Biosensors: Conceptual Design, Recent Developments, and Practical Implementation

Back Matter

Preview

Chapter Contents

Abstract
13.1 Introduction
13.2 Microcantilever-Based Biosensing
13.2.1 Surface Stress Sensing
13.2.2 Mass Sensing
13.3 Different Bio-Detection Methods
13.4 Modeling Microcantilever Beam With Adsorbed Biological Species
13.4.1 Static Mode (Deflection-Detection Method)
13.4.2 Dynamic Mode (Frequency-Response Measurement)
13.5 Recent Advances in Nanomechanical Cantilever Sensors' Modeling and Sensitivity Enhancement
13.6 Common Materials Used in Nanocantilever Biosensors
13.7 Common Methods of Nanocantilever Actuation
13.7.1 Actuation Due to Ambient Conditions
13.7.2 Actuation Using External Energy Sources
13.8 Common Methods of Signal Transduction
13.8.1 Optical Readout
13.8.2 Piezoresistive Readout
13.8.3 Piezoelectric Readout
13.8.4 Capacitive Readout
13.9 Applications
13.10 Summary
References

Excerpt

Micro∕nanocantilever-based sensors have recently emerged as an effective means for label-free chemical and biological species detection. Selectivity, low cost, and easy mass production make them an enabling technology for micro-detection and nanodetection techniques. These sensors operate through the adsorption of species on the functionalized surface of cantilevers. Through this functionalization, molecular recognition is directly transduced into a micromechanical response. This chapter presents a brief overview of microcantilever-based biosensors fabrication, the underlying principles of operation, modeling frameworks, techniques of microcantilever actuation, common materials used in fabrication of these sensors, and biological species detection techniques. More specifically, a detailed description of different operational modes of microcantilever biosensors is presented, followed by a set of comprehensive mathematical modeling frameworks. The chapter concludes with clinical applications of this type of biosensor, along with a review of recent developments and representative practical examples.

http://dx.doi.org/10.1115/1.802755.ch13